It’s no surprise that oral fluid drug testing has gained recent popularity in forensic and clinical laboratories. Not only is it easier to acquire from a sample collection perspective, but also, it’s much less invasive when comparing the measures utilized to solicit urine and blood samples. In addition, it’s much more difficult to adulterate. While there are several advantages when working with this matrix, oral fluid does have several drawbacks including lower drug concentrations, limited sample volume and preservative buffers that not only dilute the oral fluid sample but also cause ion suppression if not removed properly prior to analysis. UCT’s Clean-Screen® XCEL I solid phase extraction columns and methodology allow for a quick, efficient clean-up of oral-fluid samples providing excellent recoveries for acidic, neutral, and basic drugs in a concentrated format.