Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are conjugated ethanol biomarkers.  Due to their highly polar nature (log P of 1.51 and 0.62, respectively) and lack of retention on a traditional reversed phase HPLC column, their analysis is typically plagued by significant ion suppression when using a standard Dilute & Shoot approach. By utilizing UCT’s Clean Screen® FASt EtG filter and shoot columns in conjunction with the Selectra® EtG HPLC column, a quick and efficient overall clean-up and analysis can be executed allowing for purified extracts, significant improvements in LOD/LOQ’s, in addition to enhanced analytical column lifetime.